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October’s skies are packed with celestial surprises, from Jupiter disappearing behind the Moon to two meteor showers lighting up the darkness. NASA highlights four must-see events, including shooting stars from Halley’s Comet and a glowing Hunter’s Moon just before Halloween.

Researchers at Yale have identified a promising new approach to osteoarthritis that could do more than simply ease pain. The epilepsy drug lacosamide appears to block a protein involved in both pain signaling and cartilage destruction, helping damaged joints shift back toward repair in preclinical studies.

Scientists accidentally discovered a microscopic organism with a genetic code that breaks a rule researchers thought was nearly universal. While testing a new DNA sequencing technique, they examined a previously unknown protist collected from a freshwater pond at Oxford University. To their surprise, the organism uses two genetic signals that normally mark the end of a gene to encode two entirely different amino acids instead. These signals were previously thought to evolve together, making the discovery particularly remarkable.

A brilliant yellow coral discovered off Costa Rica proved so unusual that scientists had to create an entirely new family to classify it. The meter-tall colonies rise from seafloors covered in brittle stars, inspiring the Tolkien-inspired name Laurinque elenya, or “golden tree of the stars.” Advanced genetic analysis revealed that the coral belongs to a previously unknown evolutionary lineage.

New fossils from South Africa are reshaping the story of early human evolution. Researchers have described 18 hominin fossils from Drimolen Cave, including an adult Homo erectus skull fragment dated to about 2 million years ago, supporting evidence that the species appeared in southern Africa roughly 200,000 years earlier than long thought. The finds also reveal that Paranthropus robustus, which lived alongside Homo erectus, was gradually evolving even larger teeth and stronger chewing muscles as the climate changed.

NASA is preparing for humanity’s first Moon base with three investigations that will hunt for underground shelters, uncover hidden ice, and track dangerous conditions on the lunar surface. The findings could reveal how astronauts can survive and thrive on the Moon while laying the groundwork for future journeys to Mars.

Einstein Probe revealed nearly 10 minutes of soft X-ray activity following a short gamma-ray burst, exposing a phase of neutron star mergers that previous missions may have missed. The prolonged emission could have been powered by a newly formed magnetar and may provide a valuable new counterpart to gravitational-wave signals.

Just seven strength-training sessions helped obese mice shrink visceral fat cells and reactivate molecular pathways involved in burning stored fat, despite no change in overall body weight. The findings suggest some benefits of resistance exercise may begin long before weight loss becomes visible, though the results still need to be confirmed in humans.

A Stanford-designed molecule turns a major lymphoma-promoting protein against cancer cells, activating their own self-destruct machinery instead of simply blocking tumor growth. In mice, the treatment completely eliminated aggressive human lymphoma tumors within 11 days, although much more testing is needed before it could reach patients.

NASA’s James Webb Space Telescope is giving astronomers a glimpse of the kinds of violent collisions that may have shaped our own solar system, including the giant impact thought to have created the Moon. By studying 21 rare “extreme debris disks” around young stars, researchers found that their dust can reveal the scale and intensity of planetary collisions.

Giving zoo lions whole carcasses on a feast-and-fast schedule appears to bring out more natural behavior. The lions spent nearly three times longer feeding, engaged in more tearing and manipulating of food, and rested more heavily after meals. Their activity then increased gradually during the fasting period, closely resembling the rhythm seen in wild lions.

Physicists have found striking evidence for an unusual form of superconducting behavior in uranium ditelluride, where electron pairs organize into rippling patterns called pair density waves. Even more surprisingly, these patterns appear to survive after ordinary superconductivity disappears, suggesting that the electron pairs responsible for superconductivity may begin forming before the material actually becomes superconducting.

Blocking a receptor called P2X7 significantly reduced inflammation in human brain tissue, revealing a potential new treatment strategy for neurological and psychiatric disorders. The discovery could help researchers repurpose existing drugs for conditions including traumatic brain injury, Alzheimer’s, Parkinson’s, depression, and schizophrenia.

The James Webb Space Telescope has found strong evidence that the rocky lava world HD 3167 b has an atmosphere, despite circling its star every 24 hours under extreme heat. The surprising discovery could help scientists understand how rocky planets retain atmospheres and what the young, molten Earth may once have looked like.

Earth’s center of mass is constantly on the move, shifting by a few millimeters as enormous amounts of water, ice, and even air migrate around the planet with the seasons. NASA scientists have developed a more precise way to track these tiny swings using laser-ranging satellites, GPS data, and measurements of how water and ice deform Earth’s crust.

A study comparing 100 primate species, including humans, suggests that everyday aggression and lethal violence did not evolve as part of the same simple behavioral spectrum. Species that frequently fight or show mild aggression are not necessarily more likely to kill rivals, while extreme acts such as infanticide and lethal attacks appear to follow their own evolutionary patterns.

October skywatchers can see Saturn at opposition, catch meteors from Halley’s Comet during the Orionid peak, and watch the Moon sweep past the famous Pleiades star cluster. Moonlight may obscure some Orionids, but the best viewing should come before dawn after the Moon sets.