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The Volcker Rule: a central component of the Dodd-Frank financial reform bill and a key part of President Obama's economic legacy. Here's what it does to regulate Wall Street.

A powerful earthquake strikes Italy, North Korea launches a missile from a submarine, and a U.S. health organization releases new sugar guidelines.

Airlander 10, the world's largest aircraft, crashed during its second test flight. It suffered some cockpit damage, but Hybrid Air Vehicles has not said what caused the crash.

A 6.2-magnitude earthquake hit central Italy early Wednesday and rescuers are searching for survivors.

CNN's Anderson Cooper speaks with Susanne Craig, Boris Epshteyn and Timothy O'Brien about Donald Trump's finances.

CNN's Kyung Lah reports on the tight race that John McCain - a US senator since 1986 - finds himself in running alongside Donald Trump in Arizona.

Rep. Jason Chaffetz said that both Hillary Clinton and Donald Trump should show their medical records and their tax returns in an interview with CNN's Jim Sciutto.

One guard was killed and 21 students were injured Wednesday in an attack on the American University of Afghanistan in Kabul. CNN's Brian Todd reports.

Crews are searching for those trapped after a powerful 6.2 earthquake topples buildings in central Italy. CNN's Fred Pleitgen reports.

While only 15 years old, Ashima Shiraishi may well be the best rock climber the world has seen. CNN's Patrick Snell finds out what makes her so special.

Democratic Senator Amy Klobuchar blasted Mylan Pharmaceutical, the maker of an injection device known as EpiPens, which can save the life of someone experiencing an allergic reaction, accusing them of price gouging.

Sen. John McCain of Arizona may be facing the toughest re-election battle yet, feeling the heat from his opponent in the GOP primary as well as a Democratic challenger. CNN's Kyung Lah reports.

Sen. Amy Klobuchar, a Democrat whose daughter relies on EpiPen, urged the Senate Judiciary Committee to investigate the price increase of the medication, calling it "unjustified."

Rep. Jason Chaffetz (R-UT) called for both Clinton and Trump to release their medical records and tax returns.

Hillary Clinton is off the trail today, but her campaign is pushing back, with vigor, on an AP report raising new questions about the Clinton Foundation. CNN's Jeff Zeleny reports.

Donald Trump focused in on Hillary Clinton in a blistering speech in Tampa, Florida. CNN's Sara Murray reports.

Brand new poll numbers show Donald Trump winning in Arizona, while the race is tied in reliably Republican North Carolina. CNN's Dana Bash reports.

CNN's Atika Shubert travels to village near the earthquake epicenter in Italy where only two houses are left standing.

The "Trump effect" might be pushing Arizona Senator John McCain into the political fight of his life. CNN's Kyung Lah reports.

At least one person is dead and 21 students are injured in an attack at the American University campus in Kabul, Afghanistan.